Antipyretic Efficacy of an Initial 30-mg/kg Loading Dose of Acetaminophen Versus a 15-mg/kg Maintenance Dose

Antipyretic efficacy of an initial 30-mg/kg loading dose of acetaminophen versus a 15-mg/kg maintenance dose.

OBJECTIVE To compare the antipyretic efficacy of an initial 30-mg/kg acetaminophen loading dose versus a 15-mg/kg maintenance dose. METHODS A double-blind, parallel-group, randomized clinical trial was conducted. A total of 121 febrile (rectal temperature between 39 degrees C and 40 degrees C) but otherwise healthy outpatients who were 4 months to 9 years of age and weighed 4 to 26 kg were as...

a 30 mg/kg loading dose of acetaminophen was more effective than a 15 mg/kg maintenance dose in febrile children.

comparison of high loading dose versus usual dose of rectal acetaminophen in the treatment of febrile children

background: the superiority of antipyretic efficacy of high dose rectal acetaminophen is not well established yet. objectives: the present study aimed to compare the antipyretic effectiveness of high loading dose (30 mg/kg) and standard dose (15mg/kg) of rectal acetaminophen in febrile children. patients and methods: this triple blind randomized clinical trial was conducted on 76 patients aged ...

A dose ranging study of ibuprofen suspension as an antipyretic.

A double blind trial was conducted to determine the dose of ibuprofen suspension, which is effective in reducing the body temperature. The principal measure of efficacy was a reduction in axillary temperature of 1 degree C or more three hours after dosing. A second objective of the trial was to compare the incidence and severity of side effects and the palatability of a range of ibuprofen doses...

Re : " Equal antipyretic efficacy of oral and rectal acetaminophen : a

Equal antipyretic effectiveness of oral and rectal acetaminophen: a randomized controlled trial Title: [ISRCTN11886401]